Research

My research involves the development of Bayesian methods for the design and analysis of clinical trials. In particular, I have an interest in robust informative prior elicitation using historical data and/or expert opinion. I also have interests in subgroup estimation and identification.

Below is a list of my published papers (listed chronologically by publication/acceptance date) as well as manuscripts submitted to journals. For works in progress, please refer to my CV.

Published and Accepted Works

Statistical Methodology

  1. Ethan M. Alt, Matthew A. Psioda, and Joseph G. Ibrahim. “A Bayesian approach to study design and analysis with type I error rate control for response variables of mixed types.” Statistics in Medicine 42, no. 11 (2023): 1722-1740. https://doi.org/10.1002/sim.9696.

  2. Ethan M. Alt, Brady Nifong, Xinxin Chen, Matthew A. Psioda, and Joseph G. Ibrahim. “The scale transformed power prior for use with historical data from a different outcome model.” Statistics in Medicine 42, no. 1 (2023): 1-14. https://doi.org/10.1002/sim.9598.

  3. Ethan M. Alt, Matthew A. Psioda, and Joseph G. Ibrahim. “Bayesian multivariate probability of success using historical data with type I error rate control.” Biostatistics 24, no. 1 (2023): 17-31. https://doi.org/10.1093/biostatistics/kxab050.

  4. Ethan M. Alt, Matthew A. Psioda, and Joseph G. Ibrahim. “A hierarchical prior for generalized linear models based on predictions for the mean response.” Biostatistics 23, no. 4 (2022): 1165-1181. https://doi.org/10.1093/biostatistics/kxac022.

Collaborative Work

  1. Elvira D’Andrea, Deborah J. Wexler, Seoyoung C. Kim, Julie M. Paik, Ethan Alt, and Elisabetta Patorno. “Comparing Effectiveness and Safety of SGLT2 Inhibitors vs DPP-4 Inhibitors in Patients With Type 2 Diabetes and Varying Baseline HbA1c Levels.” JAMA Intern Med. 183, no. 3 (2023): 242–254 (2023). https://doi.org/10.1001/jamainternmed.2022.6664.

  2. Phyo T. Hoo, Julie M. Paik, Ethan Alt, Dae Hyun Kim, Deborah J. Wexler, Seoyoung C. Kim, and Elisabetta Patorno. “Risk of severe hypoglycemia with newer second-line glucose-lowering medications in older adults with type 2 diabetes stratified by known indicators of hypoglycemia risk.” The Journals of Gerontology: Series A (In Press). https://doi.org/10.1093/gerona/glad075.

  3. Allison J. Burbank, Anusha Vadlamudi, Katherine H. Mills, Ethan M. Alt, Heather Wells, Haibo Zhou, Neil Alexis, Michelle L. Hernandez, and David B. Peden. “The glutathione-S-transferase mu-1 null genotype increases wood smoke-induced airway inflammation.” Journal of Allergy and Clinical Immunology 143, no. 6 (2019): 2299-2302. https://doi.org/10.1016/j.jaci.2019.02.006.

  4. Allison J. Burbank, Michelle L. Hernandez, Katherine H. Mills, Neil Alexis, Ethan M. Alt, Haibo Zhou, and David B. Peden. “Characterizing Airway Inflammatory Responses to Wood-Smoke Inhalation.” Journal of Allergy and Clinical Immunology 143, no. 2 (2019): https://doi.org/10.1016/j.jaci.2018.12.073.

Works Under Review or In Revision

Statistical Methodology

  1. Ethan M. Alt, Xiuya Chang, Xun Jiang, Qing Liu, May Mo, H. Amy Xia, and Joseph G. Ibrahim. “LEAP: The latent exchangeability prior for borrowing information from historical data.” Journal of the American Statistical Association. (Under review).

  2. Ethan M. Alt, Brady Nifong, Xinxin Chen, Matthew A. Psioda, and Joseph G. Ibrahim. “The scale transformed power prior for time-to-event data.” Lifetime Data Analysis. (In revision).

  3. Xiaming Tan, William Wang, Donglin Zeng, Guanghan Liu, Guoqing Diao, Niusha Jafari, Ethan Alt Joseph Ibrahim. “Safety signal detection with control of latent factors.” Statistics in Medicine. (Under review).

Collaborative Work

  1. HoJin Shin, Shirley V. Wang, Dae Hyun Kim, Ethan Alt, Mufaddal Mahesri, Lily G. Bessette, Sebastian Schneeweiss, and Mehdi Najafzadeh. “Predicting treatment effects of a new-to-market drug in clinical practice based on phase III randomized trial results.” Clinical Pharmacology and Therapeutics. (Under review).
  2. Yanmin Zhu, Sonia Hernandez-Diaz, Brian T. Bateman, Kathryn J. Gray, Ethan Alt, Loreen Straub, Lockwood G Taylor, Rita Ouellet-Hellstrom, Yong Ma, Yandong Qiang, Seanna Vine, Helen Mogun, Wei Hua, Krista F. Huybrechts. “Development and validation of claims-based algorithms for estimating gestational age of spontaneous abortion and termination.”